The Butterbur herb has been used for many centuries. Butterbur herb's scientific name is (Petasites hybridus). Butterbur was traditionally used as a herbal remedy for conditions like pain, fever and spasms. Today the butterbur herb is mainly used for migraine prevention, but also for treating headaches and asthma. Pharmacologically active substances of the butterbur herb are sesquiterpenes like petasin and isopetasin.
The butterbur herb has anti-spasmodic and anti-inflammatory properties as demonstrated in pharmacological and experimental systems: it regulates calcium channels and inhibits the synthesis of the enzymes lipoxygenase and cyclooxygenase.
Efficacy and tolerability of the butterbur herb was demonstrated in two randomized, double-blind and placebo-controlled clinical trials with more than 300 adult patients and in one open trial in 108 children and adolescents.
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